Bacterial resistance towards the existing class of antibacterial drugs continues to increase,\nposing a significant threat to the clinical usefulness of these drugs. These increasing and alarming\nrates of antibacterial resistance development and the decline in the number of new antibacterial\ndrugsâ?? approval continue to serve as a major impetus for research into the discovery and\ndevelopment of new antibacterial agents. We synthesized a series of D-/L-alaninyl substituted\ntriazolyl oxazolidinone derivatives and evaluated their antibacterial activity against selected standard\nGram-positive and Gram-negative bacterial strains. Overall, the compounds showed moderate\nto strong antibacterial activity. Compounds 9d and 10d (D- and L-alaninyl derivatives bearing\nthe 3,5-dinitrobenzoyl substituent), 10e (L-alaninyl derivative bearing the 5-nitrofurancarbonyl\ngroup) and 9f and 10f (D- and L-alaninyl derivatives bearing the 5-nitrothiophene carbonyl moiety)\ndemonstrated antibacterial activity ....... against Staphylococcus aureus, Staphylococcus\nepidermidis, Enterococcus faecalis and Moraxella catarrhalis standard bacterial strains. No significant\ndifferences were noticeable between the antibacterial activity of the D- and L-alaninyl derivatives as a\nresult of the stereochemistry of the compounds.
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